Diclofenac sodium (DFN), a non steroidal anti-inflammatory drug (NSAIDS) was formulated as microspheres using Sodium Alginate (SA) as a polymer by employing ionotropic gelation technique. The prepared microspheres were made subjected for various evaluation parameters and in vitro characterization at 0.1 M HCL (pH 1.2) which is followed in 6.8 pH phosphate buffer. The particle size of microspheres was measured by using optical microscope. The prepared DFN-microsphere proves a better spherical geometry. The formulation D4 shows a better release profile in increased Sodium Alginate concentration and may also proves a better choice for site specific delivery of drug.
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